Page 13 - SKR-annual-report-2022-EN
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Sniffer dog Silja at Helsinki Airport.                          Developing a nasal spray
                                                                Covid vaccine

                                                                In 2021, the Cultural Foundation provided
                                                                around EUR 1.2 million in funding to Rokote
                                                                Laboratories Finland, which is developing a
                                                                Covid-19 vaccine in the form of a nasal spray. The
                                                                company’s aim is to begin clinical testing of the
                                                                new vaccine in Finland in 2023.

                                                                  The vaccine utilises gene transfer technology
                                                                which has been tested in several patient trials
                                                                related to cancer and cardiovascular disease
                                                                gene therapy. The objective is to respond to
                                                                challenges brought by new virus variants. In
                                                                the future, the nasal spray vaccine may act as
                                                                an easily administered booster for people who
                                                                have already received a series of traditional
                                                                vaccinations. Later on it may be possible to
                                                                create vaccines against other viruses using the
                                                                same method.

Each dog received an identical set of 114 coronavirus patient   accuracy in correctly identifying positive samples was also        PHOTOS WISE NOSE – SUOMEN HAJUEROTTELU RY AND EGIL BJÖRKMAN
samples and 306 control samples for sniffing.                   98.7 percent. Such “work motivation samples” are provided
                                                                to the dogs at regular intervals to maintain their interest in
The dogs recognized the samples correctly 92 percent of         the target odour in situations and environments where the
the time. Only small differences in accuracy were observed      proportion of positive samples is otherwise very low.
between the dogs. The study confirms previous reports
suggesting that scent dogs can identify individuals with a          “Scent dogs can provide an invaluable tool for limiting viral
coronavirus infection.                                          spread during a pandemic, serving for example at airports
                                                                and seaports. Such a reliable, cheap method of rapidly
    “Our study set-up was of a high scientific standard. The    screening a vast number of samples or of identifying passing
sample sizes were sufficiently large, and all dogs sniffed      virus carriers in a large crowd is of value particularly when
an identical set of samples, allowing comparison of their       the testing capacity with traditional methods is insufficient”,
performances. The dogs also had to successfully indicate        says Anu Kantele.
sample sets containing only negative samples. Another
significant advantage was that samples were collected from          “Our research group will continue to study how scent dogs
outpatients instead of hospital patients. In addition, the      can best help society. There are many other diseases whose
testing was performed under real-life conditions rather than    research could benefit from the excellent sense of smell that
in a laboratory”, says the leader of the DogRisk research       these dogs possess”, says Hielm-Björkman.
group and docent of clinical research on companion animals
Anna Hielm-Björkman at the University of Helsinki.                    Sniffer dog Kosti took part in high-level research.

    “I was particularly impressed by the fact that dogs
performed worse with samples we had collected from patients
suffering from a disease caused by a coronavirus variant. The
explanation is simple: The dogs had originally been trained
with the initial wild-type virus and thus they did not always
identify the variant samples as positive. This reveals their
incredible ability of discrimination”, says Anu Kantele,
Professor of Infectious Diseases and Chief Physician at the
University of Helsinki and Helsinki University Hospital.

    The third phase of the study was conducted by screening
passengers and staff at Helsinki-Vantaa Airport in a real-life
situation. The scent dogs correctly identified 98.7 percent of
the negative samples.

The low number of coronavirus-positive samples in
real-life testing prevented a proper assessment of the
dogs’ performance with positive samples. However, based
on positive samples regularly given to the dogs to improve
their work motivation during this part of the study, the dogs’
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