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FTeIMchMnology Platforms
Genomics based laser microdissection of single cells (CAMI) and
We provide tailored and high-throughput DNA and RNA data management and analysis. We work closely with
sequencing and genotyping services for medical genomics FIMM High Throughput Biomedicine unit in robotics for
and transcriptomics including primary analysis of se- cell-based high-content assays. We support research-
quencing data. Our wide variety of genomic profiling ser- ers throughout the whole process and offer individual
vices enables both the detection of novel genetic variants training on the microscopes, after which users can work
and the analysis of known genetic variants. Our services independently.
rely on expert staff and market-leading systems. For next
generation sequencing (NGS) services, we utilise Illumina’s Digital Microscopy and Molecular Pathology
NovaSeq and MiSeq platforms. These, combined with the We provide fast, high-quality and cost-efficient high
Illumina iScan genotyping platform, cover the full range throughput whole-slide scanning services for bright field
of genome and transcriptome profiling experiments on a and fluorescence wide-field microscope imaging. The
flexible scale. We also provide epigenomics (methylation) instrumentation allows both 5-channel fluorescence im-
and cell line authentication services. aging and macro-slide scanning. Image analysis services
and histo-pathological services such as building tissue
High Throughput Biomedicine microarray blocks and multiplex fluorescent immunohis-
We provide expertise in robotics, automation and the de- tochemistry staining are also available.
velopment of cell-based and biochemical assays. Our drug
sensitivity and resistance testing assay platform allows the Single-cell Analytics
testing of clinically-relevant and targeted bioactive com- We provide cutting-edge single-cell sequencing and
pounds in dose-response series against patient-derived spatial transcriptomics technologies for studies of cell
primary cancer cells or cell lines. The facility is staffed by a population heterogeneity, based on gene expression,
team of highly trained scientists with extensive experience immune profile, chromatin structure, and nucleotide
in automated assays and high throughput screening, and or copy-number variation, at single-cell resolution. In
we have state-of-the-art instrumentation, liquid handling addition, multi-omics data integration, single-cell bio-
systems, and siRNA/compound libraries necessary for informatics, and dispensing of single cells are supported.
screening. For spatial transcriptomics, both the Visium platform by
10X Genomics and the GeoMx Digital Spatial Profiler by
Metabolomics/Lipidomics/Fluxomics NanoString are available.
We offer access to high-throughput mass spectrometry-
based targeted and global metabolomics, lipidomics and Extracellular Vesicles (EV)
fluxomics. We provide rapid analysis services for metabo- We offer services that enable the study of extracellular
lites and lipids from different biological classes and various vesicles from liquid biopsy samples, including isolation
types of samples from humans and other organisms. With and analysis of EV-RNA as well as preparation of electron
our Lipidyzer platform we can target and quantify 1000 microscopy samples. Our EV Core at FIMM is part of a
lipid molecular species. We consult on and design custom joint service platform with EV Core Viikki, which provides
metabolomics methods, based on customer needs, to be orthogonal single particle analysis. Both units perform
used in precision medicine, pharmacology or basic re- EV isolations by traditional and novel methods suited to
search. In addition, through collaboration we provide me- the special requirements of each sample type.
tabolomics data analyses using bioinformatics methods.
HiPrep
High-content Imaging and Analysis We provide nucleic acid preparation and quality control
We provide access to high-content, wide-field and services and develop optimised workflows for various
spinning-disk confocal microscopy, and offer scientific biological samples in close collaboration with the FIMM
expertise in high-content imaging and image analysis. Genomics and Single-cell Analytics units and the EV Core.
Our services include high content microscopy, including
imaging in 3D and of live cells, computer assisted image-
22 | FIMM – Building a Bridge from Discovery to Medicine
